MentalHealthDaily

Whole-Body Hyperthermia for Depression: IL-6 Heat Genes

by GLOOM

Whole-body hyperthermia looks less like generic relaxation and more like a timed biological stressor: in a small depression substudy, a single session was followed by early Hamilton Depression Rating Scale improvement, heat-shock gene activation, and immune-process enrichment that included interleukin 6 production. Research Highlights Depression scores improved early: in the 18-person RNA sequencing substudy, whole-body …

Subcallosal Cingulate DBS Biomarker Predicted Depression Recovery at 72%

by GLOOM

MHD featured image for subcallosal cingulate DBS depression biomarker research.

A 2026 medRxiv preprint reported that an at-home subcallosal cingulate cortex deep brain stimulation (SCC DBS) recording system could track stable recovery in severe treatment-resistant depression: in 7 analyzable patients, the local-field-potential biomarker predicted weekly recovery states with 0.72 ± 0.16 accuracy.1 The useful claim is not that brain recordings can diagnose depression broadly; it …