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Amitriptyline Water Pollution Impaired Male Guppy Spatial Accuracy

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A 2026 Environmental Science & Technology experiment found that wild guppies still reduced maze solve times with practice after 11-day exposure to environmentally motivated amitriptyline concentrations, but exposed males made 26.35% to 34.21% more navigation errors than control males.1 The result is a sex-specific accuracy signal, not a blanket claim that antidepressant pollution erased learning. …

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Household Pesticide 3-PBA Linked to Depression Risk in 6,502 Adults

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A 2026 NHANES analysis of 6,502 adults found that urinary 3-PBA, a pyrethroid insecticide metabolite, was modestly associated with depression risk at OR = 1.02 per 1 μg/L, while self-reported household pesticide exposure weakened after full adjustment to OR = 1.43 (95% CI 0.91 to 2.25).1 The calibrated read is biomarker signal first, causal language …

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