MentalHealthDaily

Schizophrenia MRI Subtypes Split 3,958 Patients Into 2 Patterns

by GLOOM

MHD featured image for schizophrenia MRI cortical-gradient subtypes.

A 2026 ENIGMA structural MRI preprint involving 3,958 people diagnosed with schizophrenia and 5,489 controls found 2 cortical-alteration subtypes rather than 1 uniform brain pattern.1 The result maps heterogeneity: anterior-cingulate and temporoparietal network patterns may separate patients, but the result is not a diagnostic MRI test. Research Highlights Large MRI base: The analysis included 3,958 …

Drug Addiction Linked to Cortical Thinning in 65 of 68 Brain Regions

by GLOOM

Photoreal illustration of a human brain with cortical regions highlighted across substance categories, representing the cross-substance morphometric pattern in addiction.

Whether alcohol, cocaine, nicotine, and cannabis damage the same brain regions or different brain regions has been hard to settle in the addiction-imaging literature. A 2026 ENIGMA Addiction analysis by Georgiadis et al. — pooling 4,733 brains across 51 sites — now has an answer. Research Highlights Across 2,782 people with substance use disorder (SUD) …