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Dextromethorphan-Bupropion (Auvelity) for Depression: Clinical Trial Data for the New Rapid-Acting Antidepressant

Major depressive disorder (MDD) is a significant global health concern, affecting over 280 million people worldwide. While numerous pharmacological options exist, challenges remain in achieving timely, robust, and sustained antidepressant response. Dextromethorphan-bupropion is a novel oral antidepressant recently approved by the FDA for MDD in adults that may address some of these unmet needs. Key …

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How Long Does “DXM” Stay In Your System?

DXM (Dextromethorphan) is an antitussive agent comprised solely of a methylated dextrorotatory analogue of levorphanol, a semisynthetic non-opioid morphine derivative.  It is classified as a “morphinan” drug and is an active ingredient within many over-the-counter (OTC) formulations utilized to treat allergies, coughing, influenza, and more.  Examples of several popular over-the-counter formulations with DXM as an …

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