A 2026 eLife computational study modeled classical psychedelics by increasing a network state variable from alpha = 0 to alpha = 1, shifting perception from bottom-up sensory inference toward top-down generative replay. The result is a useful but still unproven oneirogen model: hallucinations look less like random noise and more like wake-time replay of a …
In the quest for innovative treatments for psychiatric disorders, the study of psychedelics has taken a significant leap forward. Among these, Dimethyltryptamine (DMT), known for its rapid onset and short duration of action, emerges as a compelling alternative to traditional therapies. Recent studies have begun to explore its potential, particularly in treating depression and anxiety, …
DMT (N,N-Dimethyltryptamine) is a psychedelic drug derived from the tryptamine family with a similar structure to serotonin and melatonin. When taken orally, DMT is generally regarded as inactive unless simultaneously ingested with an MAOI (monoamine oxidase inhibitor). An MAOI prevents the enzyme “monoamine oxidase” from rapidly oxidizing the DMT, thereby facilitating a psychedelic experience. Psychedelic …