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Eutylone Inhibits CYP2D6 Like MDMA: Polydrug Interaction Risk

MHD featured image for eutylone, CYP2D6 inhibition, and polydrug interaction risk.

A 2026 cross-species metabolism study found that eutylone, a synthetic cathinone stimulant sometimes sold as a “bath salt” or MDMA-like drug, inactivated CYP2D6 with Ki = 4.2 μM, kinact = 0.069 min-1, and inactivation efficiency = 1.64 x 10-2 min-1 μM-1 — a range the researchers described as comparable to MDMA. Research Highlights CYP2D6 was …

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How Long Does Wellbutrin Stay In Your System?

Wellbutrin (Bupropion) is an antidepressant that is hypothesized to function as a norepinephrine-dopamine reuptake inhibitor (NDRI).  It is believed to predominantly increase levels of norepinephrine and only affects dopamine to a minor extent.  As a result of its noradrenergic mechanism of action, it is considered “atypical” when compared to other serotonergic antidepressants. Unlike serotonergic antidepressants, Wellbutrin has a …

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