MentalHealthDaily

Bumetanide PROMset Study: 83% Improved in 1 Sensory-Related Domain

by GLOOM

MHD featured image for bumetanide and sensory-related parent-reported outcomes in neurodevelopmental disorders.

A 2026 medRxiv preprint using parent-cocreated sensory-related outcome measures found that 83% of children and teens improved on at least 1 PROMIS domain during 6 months of bumetanide treatment.1 The result is interesting, but the unmasked single-case design means the strongest claim is about sensitive outcome tracking, not definitive bumetanide efficacy. Research Highlights Most participants …

Autism EEG Study Finds 2 Opposite Excitation-Inhibition Subtypes

by GLOOM

Photoreal illustration of two opposing brain-network excitability profiles representing distinct autism neurosubtypes.

A 2026 medRxiv preprint did not find one simple autism excitation-inhibition signature. Bertelsen et al. found 2 EEG-derived E:I neurosubtypes in 286 autistic males: a 47% inhibition-dominant subtype with higher Hurst exponent and lower gamma, and a 53% excitation-dominant subtype with the opposite pattern.1 Research Highlights Two subtypes, opposite directions: in 286 autistic males ages …