MentalHealthDaily

Semaglutide Did Not Increase Suicidality in 102,361 Veterans

by GLOOM

MHD featured image for semaglutide and suicidality risk in veterans with type 2 diabetes.

A 2026 target-trial emulation involving 102,361 U.S. veterans with type 2 diabetes found no increased suicidality risk after starting semaglutide vs. sodium-glucose cotransporter-2 inhibitors (SGLT2 inhibitors): suicidal ideation HR 0.99 and suicide attempt/death HR 1.05 after overlap weighting.1 That does not prove semaglutide prevents suicide, but it weakens the broad claim that semaglutide initiation itself …

PGx Testing Found Actionable Genotypes in 30% of Veterans

by GLOOM

MHD featured image for pharmacogenomic testing in veteran depression and antidepressant polypharmacy.

A 12-week randomized pilot trial in 60 Veterans with depression and psychiatric polypharmacy found that 30% had an actionable antidepressant gene-drug interaction, but immediate access to pharmacogenomic results did not clearly change prescribing or Patient Health Questionnaire-9 depression scores compared with delayed access.1 Research Highlights Actionable PGx results were common: 18 of 60 Veterans, or …