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Teen Trauma Depression: fMRI Predicted Response at 82%

A 2026 adolescent depression study used resting-state functional magnetic resonance imaging to test whether childhood trauma leaves a measurable network signature in the depressed teen brain. The researchers found disrupted default-mode network hubs in teenagers with major depressive disorder and childhood trauma, and baseline functional-connectome patterns predicted treatment response with 82% accuracy.1 Research Highlights Large …

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Alpha-Synuclein SAA Predicts Parkinson’s Levodopa Response Durability

Photoreal illustration of CSF biomarker testing alongside dopaminergic neuron pathways, representing PD biomarker stratification.

A 2026 PPMI analysis found that Parkinson’s patients with positive CSF α-synuclein seed amplification assay results kept gaining levodopa benefit over follow-up, while SAA-negative patients showed faster ON-medication motor progression than SAA-positive patients: 0.87 vs. 3.47 MDS-UPDRS Part III points/year in 183 matched SAA-positive and 40 SAA-negative patients.1 Research Highlights ON-state progression split sharply: SAA-positive …

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