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Reset Modafinil Tolerance with Drug Holidays & Pitolisant-Bridging? (2023 Study)

Narcolepsy, a chronic neurological disorder, significantly impacts the daily lives of those affected due to excessive daytime sleepiness (EDS). Modafinil has been a cornerstone in managing EDS, but its effectiveness can wane over time due to tolerance. An innovative approach, using the drug pitolisant during modafinil ‘drug holidays’, offers new hope for resetting tolerance and …

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Fioricet “High”: Intoxication From Butalbital-Containing Agents

Fioricet is a medication approved by the FDA for the treatment of three specific types of headaches including: tension, muscle contraction, and post-dural puncture.  It contains a unique blend of a barbiturate (butalbital 50 mg), a pain reliever (acetaminophen 300 mg), and a stimulant (caffeine 40 mg); hence the reason it is sometimes abbreviated as Butal-Acet-Caff.  …

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Fioricet For Migraines: A Non-Evidence-Based Intervention

Fioricet is a brand name medication comprised of the following ingredients: butalbital (50 mg), acetaminophen (300 mg), and caffeine (40 mg).  The combination of a barbiturate (butalbital), a nonsteroidal anti-inflammatory drug (acetaminophen), and central nervous system stimulant (caffeine) – seem to act synergistically to alleviate various types of headaches.  Medically, Fioricet is approved by the …

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6 Common Phases Of Antidepressant Treatment

Many individuals who feel depressed believe that the smartest, most efficient way to deal with their depression is via pharmaceutical antidepressants.  Pharmaceutical antidepressants take effect quickly, altering neural connectivity within 3 hours of ingestion and manipulate neurotransmission to facilitate a mood boost.  Though antidepressants can take several weeks to fully work or “kick in,” some individuals …

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Finding the “Minimal Effective Dose” of Antidepressants & Other Drugs

When it comes to any psychotropic medication, many people simply take whatever dosage is assigned to them by their doctor. Unfortunately since most psychiatrists are bombarded with requests from patients that they want to feel better immediately, the demanding nature of the patient forces the psychiatrist to prescribe a relatively high dose. In some cases, …

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Why Antidepressants Stop Working + Solutions

Many people are taking antidepressants to treat major depression or one of the many other conditions (i.e. anxiety, PTSD, OCD) for which they are prescribed. Antidepressants are clinically effective based on scientific research, which is why they are accepted as being first-line treatment options for depression. For certain people, taking antidepressants have improved their life …

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Are Antidepressants Addictive? It’s Debatable.

Addiction is defined as repeatedly engaging in a particular behavior or using a substance to experience pleasure, regardless of the consequences. Some believe that addiction can be a result of environmental experiences and/or various psychological conditions. When most people think of addiction, they think of gambling, illicit drugs (e.g. cocaine), alcohol, and sex. One reason …

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