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SYNGAP1 Autistic Behaviors Linked to Seizure Type, Not Frequency

MHD featured image for SYNGAP1 seizure semiology and autistic behaviors.

A 337-person SYNGAP1-DEE registry preprint found caregiver-reported autistic behavior scores linked most strongly to atypical absence seizures (n = 77; FDR-adjusted p = .001), while peak seizure-frequency ratings were not detectably associated with those behavior scores.1 Research Highlights Seizure type carried the signal: atypical absences were associated with higher caregiver-reported autistic behavior scores in 77 …

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