Leigh Syndrome Brain Organoids: Azoles Rescued Lactate 20%
A 2026 Leigh syndrome study combined a cell-type-specific deep-learning screen with a 2,250-drug yeast survival screen and found the same drug family from both directions: azoles, with talarozole and sertaconazole lowering lactate release by 20% in SURF1-mutant midbrain organoids.1 The finding is preclinical, but it is stronger than a single in silico hit because the …