structure-function coupling Archives

Neonatal Brain MRI Shows Gyri Are Connectivity Hubs by 38-44 Weeks

by GLOOM

MHD featured image for neonatal MRI, cortical gyri, sulci, and early brain connectivity.

A 2026 developing Human Connectome Project analysis of 438 full-term neonates found that the newborn cortex already had an adult-like folding hierarchy: gyri connected most strongly to other gyri, sulci connected most weakly to other sulci, and structure-function coupling shifted near 41 to 42 weeks postmenstrual age.1 Research Highlights Gyri were already high-connectivity hubs: across …

TRD MRI Coupling Classified Depression Resistance Above 0.88 AUC

by GLOOM

A 2026 multimodal MRI study found that treatment-resistant depression had lower coordination between brain structure and brain activity than non-treatment-resistant depression in frontal, parietal, motor, and temporal regions. Machine-learning models using those structure-function coupling measures classified treatment-resistant vs. non-treatment-resistant depression with AUC values from 0.886 to 0.950 in the primary atlas analysis.1 Research Highlights TRD …