MentalHealthDaily

Misophonia vs Hyperacusis fMRI: 91 Adults Show Different Brain Networks

by GLOOM

Photoreal illustration of brain regions responding to sound waves with overlapping but distinct activation maps, conveying two sound-sensitivity disorder profiles.

A 2026 task-based fMRI study of 91 young adults separated misophonia from hyperacusis inside the same “sound sensitivity” experiment: misophonia-containing groups showed visual association cortex and ACC-visual network changes during unpleasant sounds, while key hyperacusis contrasts showed weaker salience-control connectivity than misophonia.1 The scan data support separating trigger-specific sound aversion from loudness-driven sound intolerance, while …

Escitalopram (Lexapro) Normalizes Brain Connectivity in Major Depression (2024 Study)

by GLOOM

Major Depressive Disorder (MDD) significantly alters the brain’s network connectivity, with disturbances in the default mode network (DMN), salience network (SN), and dorsal attention network (DAN). A new study reveals how escitalopram, a common antidepressant, can partially reverse these abnormalities, offering insights into the biological underpinnings of its therapeutic effects. This research deepens our understanding …