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Social Anxiety: Prefrontal Connectivity Differs but Amygdala-PFC Doesn’t

Stylized fMRI connectivity map showing prefrontal and amygdala circuits during emotion regulation in social anxiety disorder.

The textbook story of social anxiety disorder is broken amygdala-prefrontal regulation — an overactive threat system the prefrontal cortex can’t calm down. A 2026 effective-connectivity study of 102 adults found something different: amygdala-prefrontal connectivity didn’t differ between social anxiety patients and controls, but connectivity between prefrontal regions did, particularly involving the pre-supplementary motor area.1 Research …

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Gut Microbiome & Social Anxiety Disorder: Abnormal Bacterial Composition (2023 Study)

Recent scientific endeavors have unveiled a fascinating link between our gut microbiome and mental health, with a focus on Social Anxiety Disorder (SAD). This complex relationship, highlighting the role of microbial inhabitants in our gut in influencing our brain and behavior, marks a significant shift in understanding mental disorders. Highlights: Social Anxiety Disorder (SAD) affects …

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