MentalHealthDaily

Depression vs. Schizophrenia: Microglial TSPO and KYNA Signals

by GLOOM

MHD featured image for microglial and kynurenine pathway patterns across depression, bipolar disorder, and schizophrenia.

A 2026 systematic review found that microglia-related immune signals do not line up cleanly with psychiatric diagnosis labels: major depression showed frontolimbic TSPO-PET increases, while schizophrenia showed elevated kynurenic acid in cerebrospinal fluid.1 The strongest interpretation is that immune-brain markers may sort subgroups better than DSM categories do. Research Highlights Depression had the clearest TSPO-PET …

Inflammatory Depression Had Higher Kynurenine Metabolites

by GLOOM

A 2026 biomarker study found kynurenine-pathway activation in inflammatory major depressive disorder (MDD), but not across all depression cases. Compared with non-inflammatory MDD and healthy controls, the inflammatory subgroup had higher pathway metabolites, and omega-3 treatment reduced several of them over 8 weeks.1 Research Highlights Inflammatory depression showed kynurenine activation: people with MDD and high-sensitivity …