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Lewy Body Dementia Cognitive Fluctuations Affect 75-90% of Patients

Photoreal illustration of fluctuating brain activity overlay on an older adult, conveying alertness variability characteristic of DLB.

Cognitive fluctuations are a defining feature of dementia with Lewy bodies (DLB), helping distinguish it from Alzheimer’s disease — but they remain notoriously difficult to characterize and measure. A 2026 review by Mahajan and colleagues maps the neurobiology, measurement, and clinical implications of fluctuations across the Lewy body spectrum.1 Research Highlights Cognitive fluctuations are episodes …

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