MentalHealthDaily

Lower Uric Acid Predicted Depression in Prodromal Parkinson’s Disease

by GLOOM

MHD featured image for uric acid and depression risk in prodromal Parkinson's disease.

A 5-year PPMI cohort analysis found that lower serum uric acid independently predicted incident depression in prodromal Parkinson’s disease (HR = 0.776; 95% CI 0.619-0.974; P = 0.029).1 The signal sits beside a lower-p-value non-motor symptom predictor: higher MDS-UPDRS Part I scores also predicted depression (HR = 1.177; 95% CI 1.093-1.267; P < 0.001). Research ...

Early Parkinson’s Non-Motor Symptoms Differed by Sex After Levodopa

by GLOOM

MHD featured image for Parkinson's non-motor symptom sex differences.

A 2026 multicenter Italian cohort followed 216 early Parkinson’s disease patients for 24 months after levodopa initiation and found sex/gender differences in non-motor symptom burden.1 Women had higher anxiety, pain, mobility, and emotional-well-being burden, while men had higher hypersexuality. Research Highlights Longitudinal sample: The study followed 216 early levodopa-naive Parkinson patients, including 139 men and …