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Epilepsy and Alzheimer’s Blood Biomarkers in Older Adults

MHD featured image for epilepsy, Alzheimer’s blood biomarkers, and AT(N) profiles in older adults.

A preprint in 84 older adults with epilepsy found that abnormal Alzheimer's-related blood biomarkers were common, but the biomarker categories did not line up neatly with cognitive impairment. Research Highlights Only 32.1% had normal biomarkers: 27 of 84 older adults with epilepsy were A−T−N− using blood-based amyloid, tau, and neurodegeneration markers.1 AD-continuum profiles were common: …

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Serum MOG Blood Biomarker Rose During Multiple Sclerosis Relapse

MHD featured image for serum MOG blood biomarker levels and multiple sclerosis relapse activity.

A 2026 medRxiv case-control study found that serum myelin oligodendrocyte glycoprotein was 20.5 pg/ml higher in multiple sclerosis than in healthy donors and 15.3 pg/ml higher during relapse than remission, making it a plausible blood marker of demyelination rather than a replacement for neurofilament light chain. Research Highlights MOG was higher in MS: serum myelin …

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