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Small-Vessel Disease MRI Score Predicted 90-Day Cognition After Stroke

MHD featured image for composite small-vessel disease MRI and post-stroke cognitive recovery.

A 2026 medRxiv preprint involving 65 early subacute stroke survivors found that a composite cerebral small-vessel disease MRI score predicted 90-day cognitive recovery more reliably than any single input marker.1 Lower baseline burden predicted higher follow-up Montreal Cognitive Assessment scores (β = −0.19; p = 0.009) and remained associated after baseline cognition was included (β …

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Post-Stroke Deep Gray Nuclei MRI Predicted 3-Month Recovery

MHD featured image for post-stroke deep gray nuclei MRI and recovery prediction.

A 2026 automated MRI analysis of 153 adults with first cortical middle cerebral artery stroke found that remote deep gray nuclei changes were already measurable within 21 days, and 2 asymmetry markers independently predicted 3-month disability change: putamen volume Z-score asymmetry (β = −0.24; p = 0.021) and thalamic apparent diffusion coefficient asymmetry (β = …

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