MentalHealthDaily

Metformin’s Brain Rap1 Pathway Controlled Glucose in Mouse Study

by GLOOM

MHD featured image for metformin, brain Rap1 signaling, hypothalamic VMH neurons, and glucose control.

A 2025 Science Advances mouse study found a more brain-dependent metformin mechanism than the usual liver-gut framing suggests: low-dose metformin lost its glucose-lowering effect when brain Rap1 signaling could not be reduced, and 36 of 47 ventromedial-hypothalamus SF1 neurons responded directly to metformin.1 Research Highlights Low-dose metformin needed brain Rap1: Control mice lowered glucose after …

Metformin Prevents Antipsychotic-Induced Weight Gain: A Saudi Study Finds

by GLOOM

Research suggests that metformin may reduce weight gain associated with antipsychotic medications. Key facts: Antipsychotics are linked to weight gain, especially clozapine and olanzapine. Metformin may counteract antipsychotic-induced weight gain through effects on insulin resistance and appetite. Study found metformin reduced mean weight gain on antipsychotics from 2.5 kg to -0.04 kg. Younger patients ages …