local field potentials Archives

OCD DBS Reduced Y-BOCS 42.9% as GPe Alpha Activity Decreased

by GLOOM

MHD featured image for OCD DBS and GPe alpha activity.

A 2026 medRxiv preprint found that 10 severe obsessive-compulsive disorder patients treated with anterior-limb-of-internal-capsule DBS had a 42.9% average Y-BOCS symptom decrease over 6 months while alpha-band activity in the anterior globus pallidus externus fell.1 The strongest read is a response-marker signal: GPe alpha decreased during effective OCD DBS, but the sample is too small …

Subcallosal Cingulate DBS Biomarker Predicted Depression Recovery at 72%

by GLOOM

MHD featured image for subcallosal cingulate DBS depression biomarker research.

A 2026 medRxiv preprint reported that an at-home subcallosal cingulate cortex deep brain stimulation (SCC DBS) recording system could track stable recovery in severe treatment-resistant depression: in 7 analyzable patients, the local-field-potential biomarker predicted weekly recovery states with 0.72 ± 0.16 accuracy.1 The useful claim is not that brain recordings can diagnose depression broadly; it …