One-Pronuclear Zygotes Lost Epigenetic Marks in Mouse Study
One-pronuclear biparental zygotes may be less biologically normal than they look. In a 2026 Nature mouse study, forcing maternal and paternal genomes into 1 enlarged pronucleus disrupted early embryonic epigenetic marks, while the usual 2-pronuclear state created a cytoplasmic competition that helped preserve developmental potential.1 Research Highlights The 2026 zygote study asks why mammalian zygotes …