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Teen Trauma Depression: fMRI Predicted Response at 82%

A 2026 adolescent depression study used resting-state functional magnetic resonance imaging to test whether childhood trauma leaves a measurable network signature in the depressed teen brain. The researchers found disrupted default-mode network hubs in teenagers with major depressive disorder and childhood trauma, and baseline functional-connectome patterns predicted treatment response with 82% accuracy.1 Research Highlights Large …

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Resting HRV Sex Difference Detected in 2-5 Second Fluctuations

MHD featured image for resting heart rate variability, sex differences, and autonomic regulation.

A 2026 ECG analysis involving 269 healthy young adults found that sex differences in resting heart-rate dynamics appeared in very short 2-5 second fluctuations, not in the usual 5-minute heart rate variability averages. The short-window similarity graph metric predicted male sex with an odds ratio of 2.78 (95% CI 1.32-5.86), while conventional lnRMSSD, lnHF-HRV, and …

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