MentalHealthDaily

Syntaxin-6 Knockout Rescued Motor and Frailty Signs in Tauopathy Mice

by GLOOM

MHD featured image for syntaxin-6 knockout and tauopathy motor rescue in mice.

A 2026 humanized P301S tauopathy mouse study found that syntaxin-6 knockout partly rescued early motor impairment from months 1 to 4, protected gait at 5.5 months, reduced frailty (p = 0.0052), and reduced superficial-cortex neurodegeneration at 3 months (p = 0.0055).1 The finding strengthens syntaxin-6 as a tauopathy modifier, but it is still mouse genetics, …

Multiple Sclerosis Frailty Exercise Improved Fatigue in 6 Weeks

by GLOOM

MHD featured image for multimodal exercise, frailty, fatigue, and quality of life in multiple sclerosis.

A 2026 pilot randomized trial in 16 frail adults with multiple sclerosis found that 6 weeks of supervised multimodal exercise was feasible: retention was 87.5%, adherence was 97.2%, no adverse events were recorded, and fatigue and quality-of-life scores moved more than they did with waitlist control.1 Research Highlights Feasibility cleared the prespecified bar: 14 of …