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Music During Ketamine Did Not Improve Resistant Depression

MHD featured image for ketamine psychotherapy, treatment-resistant depression, music, and psychedelic-like treatment context.

Adding music to ketamine psychotherapy failed to provide extra antidepressant benefit over matched non-music support in a 2026 randomized clinical trial (RCT; a study that assigns participants to groups by chance), even though the full 6-infusion ketamine-psychotherapy course was followed by large depression-score reductions. Research Highlights Music added no confirmed MADRS benefit: in the MUSIK …

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