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RNAi For Depression: siRNA Targets SERT & 5-HT1A for Antidepressant Effect

It seems as though society is on the verge of ushering in a new generation of treatment modalities for depression and other psychiatric conditions.  While most people turn to pharmaceutical drugs for major depressive disorder, approximately 1 out of 3 people fail to get sufficient symptomatic relief.  To make matters worse, many end up trying …

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Rexulti (Brexpiprazole) Approved For Schizophrenia & Depression (Adjunct)

Rexulti (Brexpiprazole) is a drug that was approved July 10, 2015 for the treatment of schizophrenia and as an adjunctive option for major depressive disorder.  In clinical trials it was referred to as the chemical “OPC-34712” and is being marketed as a superior successor to Abilify (Aripiprazole) due to the fact that Abilify’s patent expired …

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Spadin (Peptide) For Depression: A TREK-1 Inhibitor Antidepressant

Depression is a growing epidemic that affects the lives of nearly 15 million Americans.  The number of individuals diagnosed with depression will continue to grow as a result of population growth, poor diet, environmental toxins, genetic polymorphisms, and other unique neurophysiological factors.  As a result of depression, it is estimated that nearly 1 out of …

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Sleep Deprivation For Depression: A Potent, Short-Term Treatment

We’ve all heard the media-driven dogma that everyone needs at least 8 hours of sleep per night for optimal neurophysiological performance.  Striving for 8 hours of sleep is generally a healthy rule of thumb [for most people], but shouldn’t be considered a utopian amount for everyone.  Many individuals diagnosed with major depressive disorder (MDD) sleep …

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L-Tyrosine Benefits & Unestablished Claims (Scientific Research)

Tyrosine is a nonessential amino acid that was discovered circa 1846.  The word “tyrosine” is derived from the Greek word “tyros” which translates roughly to “cheese.” Tyrosine is most commonly cited as “L-tyrosine” or the levorotatory “L” enantiomer due to the fact that L-amino acids are manufactured in cells and used in protein synthesis; dextrorotatory …

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Neurofeedback For Depression: An Effective Treatment?

Neurofeedback is a technique that involves training an individual to consciously alter the electrical activity (brain waves) within their brain.  The technique can be used as an intervention to improve symptoms of a variety of psychological conditions, including depression.  Individuals with depression tend to have abnormal brain wave activity compared to those without any preexisting …

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