MentalHealthDaily

D-Mannose & ACSS2 Enzyme: Rapid Depression Treatment via BDNF & TPH2

by GLOOM

Researchers have uncovered a critical role for the metabolic enzyme acetyl-CoA synthetase short-chain family member 2 (ACSS2) in depression, identifying it as a novel target for rapid-acting and long-lasting antidepressant therapies. Findings show ACSS2 regulates both brain-derived neurotrophic factor (BDNF) levels to improve synaptic plasticity and serotonin synthesis through tryptophan hydroxylase 2 (TPH2) to mediate …

Depression Linked to 12 Gastrointestinal Diseases in Genetic Analysis Study

by GLOOM

A new study published in Translational Psychiatry found evidence that genetic predisposition to depression is associated with increased risks of 12 different gastrointestinal diseases, including irritable bowel syndrome, non-alcoholic fatty liver disease, gastroesophageal reflux disease, ulcerative colitis, and more. The study helps establish a causal relationship between depression and gastrointestinal disease risk while minimizing confounding …

Statins & Depression: Antidepressant Effect by Lowering Cholesterol?

by GLOOM

Statins are among the most commonly prescribed medications worldwide. While best known for lowering cholesterol, emerging evidence suggests that statin drugs may also impact mental health – but in complex, and sometimes contradictory, ways. Key Facts: Animal and some human studies show statins may have antidepressant effects by altering neurotransmitters, promoting neurogenesis, and reducing inflammation. …

High Acid Diet & Foods Linked to Depression & Anxiety in Women

by GLOOM

A new study reveals an association between higher dietary acid load and increased risk of depression and anxiety, particularly in women. The research highlights the potential role of diet in mental health and wellbeing. Key Facts: Women with high dietary acid load had 20% higher odds of severe depression compared to those with low acid …

Adjunct Celecoxib for Depression & Mania: Treatment with a COX-2 Inhibitor

by GLOOM

Celecoxib, a selective COX-2 inhibitor, shows promise as an effective and safe adjunct treatment for major depression and mania, according to a new comprehensive systematic review. The analysis also found celecoxib improved symptoms when used as a standalone antidepressant in patients with somatic disorders. However, evidence for efficacy in bipolar depression remains unclear. Key Facts: …

Case Report: Depression Treated with Deep Brain Focused Ultrasound (2023)

by GLOOM

Deep brain stimulation using focused ultrasound leads to rapid remission of severe depression in breakthrough patient case study. Key Facts: Focused ultrasound targeted and suppressed hyperactive areas linked to depression. Stimulation lasted just 64 minutes yet caused depression remission for over 6 weeks. Approach is noninvasive and precisely targeted with no side effects observed. Technology …

Doxycycline Causes Depression, Anxiety, Suicidal Ideation?

by GLOOM

Doxycycline is a broad-spectrum tetracycline antibiotic that kills bacteria and protozoa by inhibiting protein synthesis (aminoacyl-tRNA to the mRNA-ribosome complex). The drug was patented in 1957, introduced as a pharmaceutical in 1967, and has received medical approval as a treatment for conditions such as: acne, bacterial pneumonia, chlamydia, cholera, Lyme disease, Rocky Mountain spotted fever, …