Nucleosome Distortion Pervaded Single Chromatin Fibers
Nucleosomes may be far less uniform inside living chromatin than the textbook picture suggests. In a 2026 Nature study, a single-molecule method called IDLI found that more than 85% of sampled nucleosomes in mouse embryonic stem cells showed intranucleosomal DNA accessibility, meaning the DNA wrap was partly open or distorted rather than perfectly sealed around …