P2X7 Receptors in Depression: ATP-Inflammation Target
A 2026 review in Purinergic Signalling argues that P2X7 receptors are one of the clearest molecular bridges between stress, ATP danger signaling, microglial inflammation, NLRP3 inflammasome activation, reduced BDNF, and new antidepressant drug targets.1 Research Highlights P2X7 is the lead receptor: Mattova et al. reviewed 7 ATP-gated P2X receptor subunits, with P2X7 carrying the strongest …