C9orf72 ALS Poly-GR Drives Ferroptosis via Nrf2-Slc7a11
A 2026 Cell & Bioscience study found that poly-GR, one of the toxic dipeptide-repeat proteins produced in C9orf72-linked amyotrophic lateral sclerosis (ALS), pushed motor neuron-like cells toward ferroptosis: 4-HNE lipid peroxidation rose at p < 0.0001, labile Fe²+ rose at p < 0.001, and erastin caused more cell death in poly-GR-expressing cells than in control …