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Child and Adult Adversity Doubled Frailty in UK Biobank

Editorial card showing a life-course timeline with biological aging biomarkers, illustrating how cumulative childhood and adult adversity stack on the frailty index.

A 2026 UK Biobank analysis by Aas et al. in BMC Medicine tests the “adversity leaves a fixed biological scar” framing against five biological aging markers in 153,557 middle-aged and older adults — and the marker that moves most reliably isn’t telomere length or any metabolomic clock.1 Research Highlights 153,557-participant test: Aas et al. measured …

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