MentalHealthDaily

Lithium Loading Dose Did Not Clearly Beat Standard Acute-Mania Titration

by GLOOM

Photoreal illustration of lithium tablets and blood-level monitoring chart, conveying acute-mania pharmacological strategy.

A 60-patient randomized trial of lithium loading for acute bipolar I mania reported faster serum lithium attainment than standard titration and a larger 14-day Young Mania Rating Scale (YMRS) change score, but the same accepted manuscript says absolute YMRS scores at Days 3, 7, and 14 were not significantly different between the 2 arms when …

3 New Bipolar Medications (2015): Drugs In Clinical Trials

by GLOOM

Bipolar disorder is a condition characterized by cyclical mood swings, transitioning from depression to mania (or hypomania). For a period of time, an individual with bipolar disorder will experience debilitating bouts of depression – and often unexpectedly, their entire neurophysiology will shift to facilitate a state of mania (elevated mood). Diagnostically, there are multiple types …