MentalHealthDaily

Psilocybin First Use Changed Brain Signals for 1 Month

by GLOOM

MHD featured image for first-time psilocybin use, brain entropy, MRI changes, and psychological insight.

A 2026 mechanistic study involving 28 healthy adults found that a single 25 mg psilocybin session changed acute brain entropy, psychological insight, well-being, cognitive flexibility, and some MRI-derived white-matter signals for up to 1 month. Research Highlights Acute brain entropy rose clearly: 25 mg psilocybin increased Lempel-Ziv complexity (LZc; a measure of signal irregularity) at …

Psychedelic Hallucinations May Reflect Wake-Time Memory Replay

by GLOOM

Photoreal illustration of a brain shifting between perception and generative imagery under psychedelic influence.

A 2026 eLife computational study modeled classical psychedelics by increasing a network state variable from alpha = 0 to alpha = 1, shifting perception from bottom-up sensory inference toward top-down generative replay. The result is a useful but still unproven oneirogen model: hallucinations look less like random noise and more like wake-time replay of a …