Postpartum Depression Brain Activity: 12-Study fMRI Meta-Analysis
Resting-state fMRI studies of postpartum depression have produced inconsistent results for years. A 2026 voxel-based meta-analysis pooled 12 studies of 475 patients and found 4 reliable regional differences (amygdala, precuneus, occipital, precentral cortex) at uncorrected thresholds, none of which held up under strict family-wise error correction.1 Research Highlights 12-study fMRI pool: Chen et al. analyzed …