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Coffee, Gut Microbes, Memory, and Impulsivity in 62 Adults

Stylized illustration of a coffee cup overlaid with gut bacteria silhouettes and brain neurons with neurotransmitter symbols, representing the gut-brain axis effects of habitual coffee intake.

Coffee is widely framed as cognitively friendly, but a 2026 prospective study from Boscaini et al. published in Nature Communications used shotgun metagenomics, metabolomics, and cognitive testing in 62 healthy adults to show that coffee drinkers and non-coffee drinkers differ on the gut microbiome, key neurotransmitter-related metabolites, and behavioral measures — with coffee drinkers showing …

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