Cocaine-Alcohol Relapse Shifts Prelimbic-Accumbens Circuit
Cocaine relapse circuitry looks different when alcohol is part of the history. In a rat model, inhibiting prelimbic cortex neurons projecting to the nucleus accumbens core blocked cue-triggered cocaine seeking after cocaine alone, but failed after sequential cocaine-alcohol polysubstance use.1 Research Highlights PL-NAc inhibition split by drug history: in a 4-group DREADD experiment, inhibiting the …