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Pregnancy Inflammation Linked to 79% Lower Postpartum Anxiety Odds

Stylized illustration of a pregnant silhouette with overlay of immune cells and a postpartum anxiety questionnaire, illustrating the inverse association between pregnancy inflammation indices and postpartum anxiety risk.

The depression-inflammation literature has firmly established that elevated inflammatory markers track with mood symptoms, but a 2026 study of 14,419 postpartum women from Xie et al. found the opposite pattern for postpartum anxiety: women with higher second-trimester platelet-neutrophil products and related immune-inflammation indices had substantially lower postpartum anxiety risk.1 Research Highlights Higher second-trimester PPN was …

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