MentalHealthDaily

GABA and Dopamine Shape Human Speech Control in PET-fMRI Study

by GLOOM

MHD featured image for GABA and dopamine interactions during human speech control.

A 2026 PET-fMRI study of 20 healthy adults found that GABAA receptor binding tracked speech-production brain activity across frontal, temporal, parietal, putaminal, supplementary motor, and cerebellar regions, with peak GABA-BOLD correlations reaching Rs = 0.9.1 Human speech control looks less like a pure motor-output problem and more like a task-specific balance between inhibition, dopamine, and …

Total-Body Tau PET Links Brain-Organ Coupling to Alzheimer’s Cognition

by GLOOM

Photoreal illustration of brain with cardiac and respiratory rhythm overlays, conveying brain-body coupling and AD pathology.

A 2026 total-body tau-PET study of 28 people with Alzheimer’s disease and 23 biomarker-negative controls found stronger brain-organ network connectivity in Alzheimer’s disease than in biomarker-negative controls: 35 altered connections, including 21 brain-body edges, plus AD-only links between brain-organ coupling, cortical tau burden, MRI-derived glymphatic markers, and cognition.1 The result is best read as a …