C9orf72 ALS/FTD Inflammation Linked to Microbial Glycogen in Gut
A Cell Reports study tied C9orf72-related ALS/FTD inflammation to a gut-bacterial product: inflammatory microbial glycogen appeared in 15 of 22 ALS fecal samples, 1 of 1 C9orf72-frontotemporal dementia sample, and 4 of 12 healthy controls.1 The result supports a narrower gene-by-microbial-product mechanism that makes C9orf72 loss of function more inflammatory. Research Highlights Human samples carried …