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Childhood Anxiety Linked to DNA Methylation and DMN-Limbic Development

MHD featured image for childhood anxiety, DNA methylation, and DMN-limbic network development.

A 2026 Singapore birth-cohort preprint found a conditional childhood-anxiety signal: the cord-blood DNA methylation component predicted less age-13 anxiety only in boys in the low DMN-limbic trajectory group from ages 4.5 to 10.5 years. The paper is useful for mapping developmental risk biology, but it is not a screening test and it does not show …

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