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Prolonged Antidepressant Effect of Ketamine: NMDA Receptors & Lateral Habenula “Trapping”

Ketamine causes rapid and sustained antidepressant effects that last longer than its presence in the body. This is due to ketamine getting trapped and accumulating in NMDA receptors, causing prolonged neural inhibition. Manipulating brain activity can shorten or extend ketamine’s effects. Highlights: Ketamine continues blocking NMDA receptors for 24 hours despite rapid elimination from plasma …

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