Depression vs. Schizophrenia: Microglial TSPO and KYNA Signals
A 2026 systematic review found that microglia-related immune signals do not line up cleanly with psychiatric diagnosis labels: major depression showed frontolimbic TSPO-PET increases, while schizophrenia showed elevated kynurenic acid in cerebrospinal fluid.1 The strongest interpretation is that immune-brain markers may sort subgroups better than DSM categories do. Research Highlights Depression had the clearest TSPO-PET …