Schizophrenia Risk Genes Reshape Microglial Pruning in CRISPR Screen
Schizophrenia’s genetic architecture sits awkwardly between neurons and the immune system. A 2026 CRISPR screen of 30 schizophrenia-associated genes in human microglia-like cells found that several risk genes meaningfully alter how microglia engulf synaptic material, supporting the synaptic-pruning model at the functional gene level.1 Research Highlights 30 schizophrenia risk genes were knocked out one by …