MentalHealthDaily

NOS3 TT Variant Linked to 1.72x Cognitive Risk in First-Episode Depression

by GLOOM

A 2026 cross-sectional study of 519 older adults with first-episode depression found that the NOS3 rs1799983 TT genotype was independently associated with cognitive impairment, adjusted OR 1.720 (95% CI 1.027-2.882).1 The result is strongest as a vascular-inflammation clue, not as a ready clinical genetic test. Research Highlights TT genotype carried the headline signal: in multivariable …

Gut Bacteria Composition in Major Depression vs. Healthy Controls & Antidepressant Treatment (2024 Study)

by GLOOM

Depression, a multifaceted disorder characterized by pervasive sadness and lack of interest, extends beyond the brain to implicate the entire body, including the gut. Recent research has illuminated the significant role that gut microbiota plays in Major Depressive Disorder (MDD), suggesting a complex interplay between our microbial inhabitants and mental health. Highlights: Gut Microbiota & …