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How Long Does Benadryl Stay In Your System?

Benadryl is a brand name for a variety of over-the-counter (OTC) medications containing the chemical diphenhydramine, an antihistamine.  The drug was initially synthesized in 1943, was acquired by Pfizer in 1946, and became the first antihistamine to receive FDA approval in the United States.  The brand “Benadryl” was acquired by Johnson & Johnson (from Pfizer) …

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