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Guanfacine Eases Hyperactivity in Autism; Inflammation Theory Untested

MHD card showing a teal prefrontal dendrite with a magnified membrane of closed HCN channels and an amber microglia cell inside a dashed outline, illustrating that guanfacine eased hyperactivity in autistic children while its anti-inflammatory role remains untested.

Guanfacine, a non-stimulant ADHD medication, reduced hyperactivity in autistic children in a placebo-controlled trial. A 2026 review argues it may also steady prefrontal brain signaling and calm the brain’s immune cells, but that immune effect has never been tested with guanfacine itself.1 Research Highlights Hyperactivity fell in the largest autism trial: in 62 autistic children, …

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