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Droperidol vs. Midazolam for Extreme Agitation in Dutch EDs

MHD featured image for droperidol, midazolam, and emergency sedation for extreme agitation.

A 2026 national survey of Dutch emergency physicians found wide variation in first-line medication choices for extreme agitation: without intravenous access, 34.7% preferred midazolam, 23.1% preferred droperidol, 14.3% preferred droperidol plus midazolam, and 10.4% preferred esketamine.1 The result is a practice map, not an outcome trial, but it shows how emergency clinicians are balancing rapid …

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Excited Delirium Syndrome: Causes, Symptoms, Treatment

Excited delirium is considered a relatively uncommon health condition characterized by severe agitation, aggression, distress, and is often fatal.  In many cases of excited delirium, individuals will have displayed noticeable increases in body temperature (fever), utilized drugs that altered dopaminergic functioning, and exhibit overtly bizarre behavior.  Although the condition is rare, those with excited delirium …

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