endothelial dysfunction Archives

NOS3 TT Variant Linked to 1.72x Cognitive Risk in First-Episode Depression

by GLOOM

A 2026 cross-sectional study of 519 older adults with first-episode depression found that the NOS3 rs1799983 TT genotype was independently associated with cognitive impairment, adjusted OR 1.720 (95% CI 1.027-2.882).1 The result is strongest as a vascular-inflammation clue, not as a ready clinical genetic test. Research Highlights TT genotype carried the headline signal: in multivariable …

High Remnant Cholesterol Levels Linked to Depression Risk in U.S. Adults

by GLOOM

Remnant cholesterol (RC), also known as triglyceride-rich lipoproteins, has been gaining increasing attention in recent years due to evidence linking it to cardiovascular disease, diabetes, chronic kidney disease, and other conditions. A new study suggests that elevated levels of remnant cholesterol in the blood may be associated with an increased risk of depression. Key Facts: …