OCD DBS Reduced Y-BOCS 42.9% as GPe Alpha Activity Decreased
A 2026 medRxiv preprint found that 10 severe obsessive-compulsive disorder patients treated with anterior-limb-of-internal-capsule DBS had a 42.9% average Y-BOCS symptom decrease over 6 months while alpha-band activity in the anterior globus pallidus externus fell.1 The strongest read is a response-marker signal: GPe alpha decreased during effective OCD DBS, but the sample is too small …